In every country around the globe, bacterial resistance to antibiotics is a serious problem. Investigating new antibacterial medication sources is necessary in light of this. Tetracycline resistance is brought about through changes to the ribosome binding site and/or the development of mobile genetic elements carrying genes for resistance to tetracycline's.
The objective of the study:
The creation of new tetracycline antimicrobial analogues and testing of their in vitro antibacterial activity.
Methodology:
The current investigation was a screening experimental study. This research determined the minimum inhibitory concentrations (MI-Cs) of growth of several pathogenic microbes in Egypt by evaluating the in vitro antibacterial new tetracycline analog activity semi-synthetically synthesized from Streptomyces species. Tetracycline was purified using aqueous two-phase systems with polyethylene glycol and salts based on cholinium, which were then altered using chemo-informatics. The tetracycline analog A (nitrocycline) was created by adding an electron-withdrawing nitro group at position 7 of the tetracycline.
Results:
Although it showed less bacterial resistance than tetracycline, the antibiotic nitrocycline (tetracycline analogue A) was a more effective bacteriostatic antibacterial agent. When compared to the tetracycline prototype antibiotic, tetracycline analogue A demonstrated MICs of less than 10 micrograms/ml for bacterial growth, reflecting its potent antimicrobial activity.
Conclusion:
The development of a nitrocycline antibiotic with a broad range of activity, which helps in addressing the formidable problem of bacterial resistance, made this study intriguing.
Kassab, M. (2023). New antimicrobial tetracycline analogue A (Nitrocycline) designed using chemoinformatics. International Journal of Health Sciences (Egypt), (), -. doi: 10.21608/ijhegy.2023.213460.1029
MLA
Mohammed M Kassab. "New antimicrobial tetracycline analogue A (Nitrocycline) designed using chemoinformatics", International Journal of Health Sciences (Egypt), , , 2023, -. doi: 10.21608/ijhegy.2023.213460.1029
HARVARD
Kassab, M. (2023). 'New antimicrobial tetracycline analogue A (Nitrocycline) designed using chemoinformatics', International Journal of Health Sciences (Egypt), (), pp. -. doi: 10.21608/ijhegy.2023.213460.1029
VANCOUVER
Kassab, M. New antimicrobial tetracycline analogue A (Nitrocycline) designed using chemoinformatics. International Journal of Health Sciences (Egypt), 2023; (): -. doi: 10.21608/ijhegy.2023.213460.1029
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