Effect of Nandrolone Decanoate on the liver of Adult Male Albino Rats and the Possible ameliorating role Of Taurine

Document Type : Original Article

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Human Anatomy and Embryology department, Faculty of medicine, Zagazig university

Abstract

Background:  Nandrolone decanoate (NDD) is a widely used anabolic androgenic steroid as it exhibits androgen-like properties, anabolic effects, and liver-damaging effects. The study's aim is to assess the hepatotoxic damage caused by NDD in adult male albino rats and to elucidate any potential protective effect of taurine in the reduction of this damage.  Thirty adult male albino rats were used in this study and were randomly divided into three groups:  Control group consisted of 10 rats that did not receive any treatment and received only good diet for 8 weeks. Nandralone treated (NDD) group: contained 10 rats were injected intramuscularly (by Nandrolone decanoate (5mg/kg B.w) twice / week for 8 weeks.   NDD+Taurine group: consisted of 10 rats that had received Nandrolone decanoate by intramuscular injection at a dose of 5mg/kg body weight twice a week for 8 weeks and Taurine by oral gavage at a dose of 100mg/kg body weight every day for 8 weeks The hepatic cells in the NAD-treated group had harmful changes, including dilated, obstructed central and portal veins, a proliferating bile duct, enlarged collagen fibers, and a robust response to caspase 3 and alpha smooth actin. While the NDD+Taurine group showed  moderate improvement in general architecture of the liver . Conclusion: The study verified the protective effect of Taurine administration on Nandrolone induced hepatic damage.

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